Crestor Shown to Cut Deaths and Heart Attacks

From the New York Times:

A large new study suggests that millions more people could benefit from taking the cholesterol-lowering drugs known as statins, even if they have low cholesterol, because the drugs can significantly lower their risk of heart attacks, strokes and death.

The study, involving nearly 18,000 people worldwide, tested statin treatment in men 50 and older and in women 60 and older who did not have high cholesterol or histories of heart disease. What they did have was high levels of a protein called high-sensitivity C-reactive protein, or CRP, which indicates inflammation in the body.

The study, presented Sunday at an American Heart Association convention in New Orleans and published online in The New England Journal of Medicine, found that the risk of heart attack was more than cut in half for people who took statins.

Those people were also almost 50 percent less likely to suffer a stroke or need angioplasty or bypass surgery, and they were 20 percent less likely to die. The statin was considered so beneficial that an independent safety monitoring board stopped what was supposed to be a five-year trial last March after less than two years.

From CNN:

Healthy men and women with good cholesterol levels could significantly reduce their risk of heart disease by taking cholesterol-lowering drugs, better known as statins, according to a study released Sunday.

Nearly 18,000 people in 26 countries, including 7,000 women and nearly 5,000 minorities, participated in the clinical trial, the results of which were published in The New England Journal of Medicine.

All had very good cholesterol levels, with average LDL — or “bad” cholesterol — levels of 108 and average HDL –or “good” cholesterol — levels of 49.

However, each participant had elevated levels of “high-sensitivity C-reactive protein” or hs-CRP — a marker that indicates inflammation in the body and can contribute to coronary heart disease, the No. 1 killer of men and women in the United States.

Under the current guidelines set for lowering cholesterol levels, none of the participants would have qualified for taking statins.

In the study, the participants took 20 milligrams of the drug Rosuvastatin — commercially known as Crestor — or a placebo pill.

Reported by Kreuzer's Korner.