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Police say the couple and their two-month-old daughter were holidaying in Cairns when the baby became critically ill on Sunday.
Paramedics rushed her to Cairns Base Hospital were she is now in a stable condition.
Police allege the baby had been given half a tablet of ecstasy.
They have charged her 24-year-old father and 22-year-old mother with grievous bodily harm and possessing a dangerous drug.
The couple, who cannot be identified for legal reasons, made a brief appearance in the Cairns Magistrates Court this morning.
They were not required to enter a plea.
The matter was adjourned until next month so police can prepare a brief of evidence.
By ABC Australia