A recent study conducted at Mayo Clinic suggests that high levels of one of the natural insulin-like proteins involved in regulating tissue growth and maintenance in the body, Insulin-Like Growth Factor Binding Protein-2 (IGFBP-2), also may be an indicator of low bone density and high rates of bone loss in older women and men.
The study concluded that high IGFBP-2 levels affect various bones and various sites of bone differently for older women and men. It provided novel insight on likely differences in the regulation of bone loss, not only by age and gender, but by bone site.
"Adjusting for age, we found no association between IGFBP-2 and bone loss in premenopausal women or men younger than 50," says Shreyasee Amin, M.D., Mayo Clinic rheumatologist.
"In postmenopausal women, however, high IGFBP-2 levels were associated with bone loss at all sites except the spine."-Mayo Clinic
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