New NO-releasing polymers with potential medical uses

Joseph A. Hrabie, of the National Cancer Institute at Frederick, and colleagues at Northwestern University report synthesis of NO-releasing forms of the most commercially important polyacrylonitrile (PAN) polymers. The new polymers include a textile, a plastic and a rubber. Some of the materials continuously release small amounts of NO for months. NO dilates blood vessels and has other actions suggesting that it could reduce undesirable effects such as blood vessel scaring and narrowing that tend to occur after coronary angioplasty and bypass surgery.

In experiments with laboratory rats, the researchers showed that a NO-releasing variant of PAN powder, applied after balloon angioplasty, reduced formation of scar tissue in the artery. "Many applications of this chemistry in vascular surgery and other medical procedures can be envisioned," the report states. "Possible applications of these polymers include arterial stenting, bypass grafting and surgical endarterectomy."-American Chemical Society