Researchers provide new details about how proteins orchestrate cell division.
Cells can divide only when certain key proteins are activated and others inhibited. A protein called NIPA and a set of two proteins called cyclin B1 and Cdk1 are some of these key proteins. Until now, scientists had shown that the cyclin B1/Cdk1 complex is needed to initiate and maintain cell division but is destroyed before and after this process. Also, NIPA was shown to regulate the abundance of cyclin B1/Cdk1 before cell division.
Justus Duyster, Florian Bassermann, and their colleagues revealed that cyclin B1/Cdk1 also regulates NIPA during cell division, which indicates that both proteins regulate each other. The scientists suggest that NIPA is inhibited twice: directly before cell division, to activate cyclin B1/Cdk1, and at the beginning of cell division, when NIPA is further inhibited by cyclin B1/Cdk1. At the end of cell division, cyclin B1/Cdk1 is destroyed and NIPA becomes active again.-American Society for Biochemistry and Molecular Biology
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