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"I really am just a girl from a little town in Georgia, who had this giant, absurd dream," said the Oscar-winning actress, who accepted the 22nd annual American Cinematheque Award at a benefit dinner in Beverly Hills.
Many of Roberts's current and former co-stars were on hand to offer praise for the 39-year-old mother of three.
"Everybody loves Julia Roberts. Everybody, everybody, everybody," said actor Tom Hanks, who stars with Roberts in the upcoming Charlie Wilson's War.
Roberts won an Academy Award for her portrayal of a legal crusader in the 2000 film Erin Brockovich.
She is also well known for roles in films including My Best Friend's Wedding, Steel Magnolias, Mystic Pizza and Ocean's Eleven.
Though honoured for her contributions to the film industry, Roberts said she is most proud of her roles as a wife and mother.
She thanked her husband, cameraman Danny Moder, for widening her life - and her hips.
Roberts married Moder, 38, in 2002.
They have three children, Phinnaeus, Hazel and Henry. © 2007 Australian Broadcasting Corporation