Scientists at the Gladstone Institute of Neurological Disease (GIND) have identified a new strategy to destroy amyloid-beta (AB) proteins, which are widely believed to cause Alzheimer's disease (AD). Li Gan, PhD, and her coworkers discovered that the activity of a potent AB-degrading enzyme can be unleashed in mouse models of the disease by reducing its natural inhibitor cystatin C (CysC).

Scientists at the Gladstone Institute of Neurological Disease (GIND) and the University of California have found that complete or partial removal of an enzyme that regulates fatty acid levels improves cognitive deficits in a mouse model of Alzheimer's disease (AD).

Amyloid precursor protein (APP), whose cleavage product, amyloid-b (Ab), builds up into fibrous plaques in the brains of Alzheimer's disease patients, jumps from one specialized membrane microdomain to another to be cleaved, report Sakurai et al.

A new study published in Bioscience Hypotheses, a recently launched Elsevier journal, proposes that some people suffering from Alzheimer's disease experience a reduction in their high blood pressure because of cognitive decline.

A new study suggests that seniors who line dance, play bridge or a musical instrument may be doing more than just having fun: They may be warding off the risk of developing dementia, including Alzheimer’s, a progressive brain disease which afflicts 5.2 million Americans.

A simple blood test to detect whether a person might develop Alzheimer's disease is within sight and could eventually help scientists in their quest toward reversing the disease's onset in those likely to develop the debilitating neurological condition.

Treatment of hypertension has proven to reduce cardiovascular risk substantially, but a large proportion of people with hypertension in the general population are not even diagnosed or treated.

For the first time, researchers have described hour-by-hour changes in the amount of amyloid beta, a protein that is believed to play a key role in Alzheimer's disease, in the human brain. A collaborative team of scientists at Washington University School of Medicine in St. Louis and the University of Milan report their results this week in Science.

Living with a spouse or a partner decreases the risk of developing Alzheimer's and other dementia diseases. This according to a study by Krister Håkansson, researcher in psychology at Växjö University and Karolinska Institutet, Sweden. The results were presented for the first time yesterday at the world's largest dementia conference.

NewYork-Presbyterian Hospital/Weill Cornell Medical Center announced today the nine-month interim results of an ongoing Phase II clinical trial of GAMMAGARD Intravenous Immunoglobulin (IGIV) for Alzheimer's disease at the Alzheimer's Association International Conference on Alzheimer's Disease (ICAD) in Chicago

Alzheimer's disease is the end result of gradual, progressive brain aging. Positron emission technology (PET) scans of patients' brains typically reveal a decreased rate of metabolism, a hallmark of the disorder.

A maternal history of Alzheimer's disease appears to predispose individuals to the mind-robbing disease because their brains aren't using glucose efficiently, according to new findings presented at the Alzheimer's Association 2008 International Alzheimer's Disease Conference held in Chicago.