In this ongoing quest, a group of Scripps Research Institute scientists, along with colleagues from the University of California, San Diego, (UCSD) have borrowed from physics to deliver one of those research rarities—an unmitigated success. The group has devised a computational method that, with remarkable accuracy, predicts how bacterial proteins fold and interact.

Researchers from the UCLA Henry Samueli School of Engineering and Applied Science have taken a major step forward in the field of metabolic engineering, successfully using the bacterium Escherichia coli to synthesize a class of natural products known bacterial aromatic polyketides, which include important antibiotic and anticancer drugs.

Infectious disease experts warn that new drugs are urgently needed to treat six drug-resistant bacteria that cause most hospital infections and increasingly escape the effects of antibiotics.

Antibiotics are the single largest class of agents that cause idiosyncratic drug-induced liver injury (DILI), reports a new study in Gastroenterology, an official journal of the American Gastroenterological Association (AGA) Institute.

Rhode Island Hospital researchers report that findings from a new study of retail meat in the Providence, RI area indicate little to no presence of antibiotic-resistant bacteria. The study, prompted by the identification of such organisms in retail meat in Canada, Europe and Asia, is among the first in this country to look at the possible spread of infection through retail meat.

Chemistry researchers at The University of Warwick and the John Innes Centre, have found a novel signalling molecule that could be a key that will open up hundreds of new antibiotics unlocking them from the DNA of the Streptomyces family of bacteria.

Many rheumatologists and general internal medicine physicians in the US say they regularly prescribe "placebo treatments" including active drugs such as sedatives and antibiotics, but rarely admit they are doing so to their patients, according to a study on bmj.com today.

Scientists have taken a critical step toward the development of new and more effective antibacterial drugs by identifying exactly how a specific antibiotic sets up a road block that halts bacterial growth.

Chemicals used in the environment to kill bacteria could be making them stronger, according to a paper published in the October issue of the journal Microbiology. Low levels of these chemicals, called biocides, can make the potentially lethal bacterium Staphylococcus aureus remove toxic chemicals from the cell even more efficiently, potentially making it resistant to being killed by some antibiotics.

The last decade has seen a dramatic decline in the effectiveness of antibiotics, resulting in a mounting public health crisis across the world. A new breakthrough by University of Virginia researchers provides physicians and patients a potential new approach toward the creation of less resistant and more effective antibiotics.

University of Illinois microbiology professor William Metcalf and his collaborators have developed a way to mass-produce an antimalarial compound, potentially making the treatment of malaria less expensive.

Researchers in Florida are reporting an advance toward tapping the enormous potential of an emerging new group of antibiotics identical to certain germ-fighting proteins found in the human immune system.