An interdisciplinary team of researchers at Vanderbilt University has analyzed the simplest known biological clock and figured out what makes it tick. The results of their analysis are published in the March 27 issue of the journal Public Library of Science Biology.
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Disrupt the gene that regulates the biological clocks in mice and they become manic, exhibiting behaviors similar to humans with bipolar disorder, UT Southwestern Medical Center researchers have found.
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A central pacemaker structure in the brain controls diurnal rhythms of behavior and hormone release. However, biological clocks are also encountered in almost every cell type (so-called "peripheral"Â clocks), in which they regulate daily changes in cell biology, including cell division. Very little is known to date about how the two clock systems interact.
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The temperature hovers around freezing, but the sun is up for 24 hours each day. How do animals living in the continuous light of the Arctic summer know when to sleep and when to be active? Do they maintain a 24-hour cycle of rest and activity, or does living in continuous light alter their circadian rhythm?
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