Oregon Health & Science University Cancer Institute researchers have found that an experimental drug known as SGX393 is effective against Gleevec-resistant chronic myeloid leukemia (CML). The results of their study will be published the week of March 24th in the Proceedings of the National Academy of Sciences.

A standard part of testicular cancer care isn’t used in more than half of all patients who have the condition, researchers at the University of Michigan Comprehensive Cancer Center have found.

Clinicians have been perplexed by the fact that some patients given the drug cetuximab—an immune-based therapy commonly used to treat persons diagnosed with head and neck cancer, or colon cancer—have a severe and rapid adverse reaction to the drug.

AstraZeneca (NYSE: AZN) announced today that it has completed patient enrollment in two pivotal Phase III studies for vandetanib, the company’s investigational, once-daily oral anti-cancer drug, for the second-line treatment of non-small cell lung cancer (NSCLC).

A novel drug that fully eliminated brain tumors from mice in a dramatic 2004 study has shown a darker side—causing permanent bone damage in younger mice. The researcher who conducted both studies says the disappointing new finding raises concerns about using similar drugs to treat children’s cancers, at least until there is a more thorough understanding of possible risks.

Researchers in Germany report an advance toward the much awaited era in which scientists will discover and design drugs for cancer, arthritis, AIDS and other diseases almost entirely on the computer, instead of relying on the trial-and-error methods of the past.

In a move to bolster its cancer treatment drug supply Pfizer said that it has reached a deal with Serenex to buy the pharmaceutical drug company.

If the genome is the parts list of the human cell, certain proteins are the production managers, activating and deactivating genes as needed. Scientists funded by the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health, now have a clearer understanding of how a key protein controls gene activity and how mutations in the protein may cause disease.

A rare disorder caused by an excess of two types of immune cells—the mast cell found in various tissues and its blood-based twin, the basophil—has successfully been treated with a cancer drug, report scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).

New research by scientists at Schepens Eye Research Institute may help explain why the anti-cancer drug Avastin, which targets a growth factor responsible for creation of new blood vessels, causes potentially fatal brain inflammation in certain patients.

A collaborative team of researchers spearheaded by Dennis Carson M.D., professor of medicine and director of the Rebecca and John Moores UCSD Cancer Center at the University of California, San Diego (UCSD) has identified a potent new anti-cancer drug isolated from a toxic blue-green algae found in the South Pacific.

The cancer drug Avastin (bevacizumab) is used to treat advanced bowel cancer in combination with chemotherapy. This drug targets a protein called VEGF (vascular endothelial growth factor) that stimulates blood vessel growth.