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Protein prevents DNA damage from persisting through generations

A protein long known to be involved in protecting cells from genetic damage has been found to play an even more important role in protecting the cell's offspring.

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Secrets of chromosome movement

Investigators at St. Jude Children's Research Hospital have used the lowly yeast to gain insights into how a dividing human cell ensures that an identical set of chromosomes gets passed on to each new daughter cell.

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Important secret in gene replication uncovered

A team of researchers led by University of Virginia Health System geneticists has uncovered a major secret in the mystery of how the DNA helix replicates itself time after time. It turns out that it is not just the sequence of the bases (building blocks) in the DNA, but also how loosely or tightly the chromatin (the material that makes up chromosomes) is packed at different points of the chromosome that is critical.

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Researchers shed light on shrinking of chromosomes

A human cell contains an enormous 1.8 metres of DNA partitioned into 46 chromosomes. These have to be copied and distributed equally into two daughter cells at every division. Condensation, the shortening of chromosomes, allows the cell to handle such huge amounts of genetic material during cell division and helps preventing fatal defects in chromosome separation.

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Proteins that Distinguish Chromosome Ends from DNA Double-Strand Breaks

Peter Baumann, Ph.D., Assistant Investigator, and Nancy Bae, Ph.D., Postdoctoral Research Associate in the Baumann Lab, have published a paper offering insight into the way cells protect chromosome ends from misguided repair.

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Could USA presidential DNA trail reveal Middle-Eastern origins?

DNA testing carried out by University of Leicester geneticists and funded by The Wellcome Trust has thrown new light on the ancestry of one of the USA's most revered figures, the third President, Thomas Jefferson.

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Researchers identified Autism gene

Yale School of Medicine autism experts Fred Volkmar, M.D. and Ami Klin are part of a global research consortium from 19 countries to identify a gene and a region of a chromosome that may lead to autism in children.

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Risk-factor genes identified for type 2 diabetes

A new study led by researchers at the McGill University Health Centre (MUHC) has identified four genes that increase the risk of developing type 2 diabetes. This form of diabetes is the most common worldwide and affects nearly 2 million Canadians. In recent years, the prevalence of Type 2 diabetes has increased rapidly. This genetic discovery may help stem this rise.

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Genes found that may contribute to autism

An international team of researchers from 19 countries has identified one gene and a previously unidentified region of another chromosome as the location of another gene that may contribute to a child's chances of having autism.

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Shortening cancer onset in families with rare syndrome

In families with a high incidence of Li-Fraumeni syndrome, the ends of individuals' chromosomes act somewhat like a lit fuse, according to researchers at The Hospital for Sick Children in Toronto. Their findings detail how telomeres, the ends of the chromosomes, shorten with every successive generation, leading to more severe cancers at an earlier age.

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DNA ends: Common tool, different job

Every time a cell repairs or replicates its DNA, the resulting single strand is wrapped up by a dedicated protein complex. In eukaryotes or organisms whose cells have a nucleus, this job is handled by a tripartite complex called replication protein A (RPA).

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Microtubule protein interactions visualized en masse

In a new study published online in the open access journal PLoS Biology, Philipp Niethammer, Eric Karsenti, and colleagues investigate the regulation of microtubule dynamics via application of their new method, called visual immunoprecipitation (VIP), which enables simultaneous visualization of multiple protein interactions in cell extracts.

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