A new study says targeting smaller (Îì5 mm) lesions does little to significantly reduce the incidence of colorectal cancer (CRC) and, in fact, results in extremely high financial costs and a large proportion of adverse events.
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Mutations in the KRAS oncogene could predict a lack of response to the drug cetuximab in patients with colorectal tumors. For those with the mutations, the drug is likely to be inefficient and possibly harmful, according to researchers at France's Institut National de la Sante et de la Recherche Medicale (INSERM).
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A phase III trial of 1,298 colorectal cancer patients has found that a combination of the drugs cetuximab (Erbitux) and irinotecan showed a significant improvement in progression-free survival over just irinotecan alone, according to an international team of researchers.
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Patients with a variant of a DNA repair gene, known as MLH1, may have an increased risk of a subtype of colorectal cancer.
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A single surgery to remove cancer from both the colon and the liver to which it has spread may be better in some cases than the current standard treatment of two separate surgeries with chemotherapy in between, according to a study led by Duke University Medical Center researchers.
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Colorectal cancer patients who undergo colonoscopic surveillance during follow-up after surgery experience improved survival, according to a study to be published in the April issue of Clinical Gastroenterology and Hepatology but currently available on-line.
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Even when diagnosed with a condition that is a strong genetic predictor of colorectal cancer, many patients do not seek out genetic counseling or cancer screening. According to a recent study in The American Journal of Gastroenterology, counseling and screening rates could be improved if physicians provided stronger encouragement and more complete information about the benefits of screening to their patients.
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Two new vitamin D studies using a sophisticated form of analysis called meta-analysis, in which data from multiple reports is combined, have revealed new prescriptions for possibly preventing up to half of the cases of breast cancer and two-thirds of the cases of colorectal cancer in the United States. The work was conducted by a core team of cancer prevention specialists at the Moores Cancer Center at University of California, San Diego (UCSD), and colleagues from both coasts.
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Researchers believe they have discovered by chance a new way to fight colorectal cancer, and potentially cancers of the esophagus, liver and skin. Early work shows that a group of compounds called peroxisome proliferator-activated receptor-gamma (PPARgamma) inhibitors may have an unexpected cancer-fighting effect, according to research published today in the journal International Cancer Research.
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Scientists at the University of Liverpool have found how two molecules fight in the blood to control the spread of cancer cells
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Teachers College study finds telephone outreach dramatically increases use of a potentially life-saving procedure
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African-Americans with health insurance still face worse outcomes in colorectal cancer than Caucasians, Hispanics, and Asians, according to a new study. Published in the February 1, 2007 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study reveals that differences in utilization of screening tests and surgical treatment may contribute to poorer colorectal cancer survival rates in African-Americans.
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