There have been several revolutions during the 60 year history of electronic computation, such as high level programming languages and client/server separation, but one key challenge has yet to be fully resolved.

With the aid of more than 70,000 home computer users throughout the world, Howard Hughes Medical Institute (HHMI) researchers have, for the first time, accurately predicted the three-dimensional structure of a small, naturally occurring globular protein using only its amino acid sequence.