The herpes simplex virus (HSV) can infect the eye and sometimes causes so much damage that the person's cornea must be replaced with a transplant. (The cornea is the clear covering of the front of the eye that helps focus light for vision.) Doctors knew transplants were more likely to fail in people with herpes simplex virus than in patients with other disorders, such as keratoconus, an abnormal steepening of the cornea.

Stem cells collected from human corneas restore transparency and don't trigger a rejection response when injected into eyes that are scarred and hazy, according to experiments conducted in mice by researchers at the University of Pittsburgh School of Medicine. Their study will be published in the journal Stem Cells and appears online today.

Does season of birth play a role in the development of nearsightedness? Do corneas from older donors meet quality standards for transplant surgery? These are among the topics explored in the April 2008 issue of Ophthalmology, the journal of the American Academy of Ophthalmology.

One donor cornea may be divided and transplanted into multiple patients with eye disease or damage, according to a report in the April issue of Archives of Ophthalmology, one of the JAMA/Archives journals.