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How Gel Influences On DNA Movement

Molecular biologists, including the cool dudes from CSI, use gel electrophoresis to separate DNA fragments from each other in order to analyse the DNA. A team of researchers under the leadership Serge Lemay, has now shown for the first time how the gel influences the movement of the DNA. The researchers drove a single DNA molecule through a nanopore in order to analyse the forces on the DNA.

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New DNA sensors could identify cancer using only one atom thick

Kansas State University engineers think the possibilities are deep for a very thin material.

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DNA differences may influence risk of Hodgkin disease

A new analysis has found that certain variations in genes that repair DNA can affect a person's risk of developing Hodgkin disease. Published in the April 1, 2009 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study indicates that differences in these genes should be further investigated to better understand individuals' susceptibility to this type of cancer.

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Large DNA stretches, not single genes, shut off as cells mature

Experiments at Johns Hopkins have found that the gradual maturing of embryonic cells into cells as varied as brain, liver and immune system cells is apparently due to the shut off of several genes at once rather than in individual smatterings as previous studies have implied.

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DNA repair patterns may predict risk of pancreatic cancer

Genetic variations in DNA repair patterns may increase risk of pancreatic cancer by as much as threefold or decrease it by as much as 77 percent, depending on the genes involved, according to a report published in the January 15, 2009, issue of Clinical Cancer Research, a journal of the American Association for Cancer Research.

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Scientists develop first examples of RNA that replicates itself indefinitely

Now, a pair of Scripps Research Institute scientists has taken a significant step toward answering that question. The scientists have synthesized for the first time RNA enzymes that can replicate themselves without the help of any proteins or other cellular components, and the process proceeds indefinitely.

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Crohn's disease susceptibility increasing gene discovered

Researchers at McGill University, the Research Institute of the McGill University Health Centre (RI MUHC) and the McGill University and Génome Québec Innovation Centre, along with colleagues at other Canadian and Belgian institutions, have discovered DNA variations in a gene that increases susceptibility to developing Crohn's disease.

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Perfectionist protein-maker trashes errors

The enzyme machine that translates a cell's DNA code into the proteins of life is nothing if not an editorial perfectionist.

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Studying DNA repair and protein modification

This month's issue of Cold Spring Harbor Protocols features two articles detailing experimental methods for the analysis of molecular processes involved in DNA repair and post-translational modification of proteins.

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Using nanoparticles to make 3-D DNA nanotubes

Arizona State University researchers Hao Yan and Yan Liu imagine and assemble intricate structures on a scale almost unfathomably small. Their medium is the double-helical DNA molecule, a versatile building material offering near limitless construction potential.

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In lung cancer, silencing one crucial gene disrupts normal functioning of genome

While examining patterns of DNA modification in lung cancer, a team of international researchers has discovered what they say is a surprising new mechanism. They say that "silencing" of a single gene in lung cancer led to a general impairment in genome-wide changes in cells, contributing to cancer development and progression.

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Guiding genetic genealogy labs toward improved accuracy

Anyone who has watched crime dramas on TV knows that forensic scientists can use DNA “profiling” to identify people from evidence gathered at a crime scene, establish a paternity link or help free an innocent person who has been wrongly jailed.

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