Frontal lobe dementia (Frontotemporal Dementia, FTD) strikes people at an earlier age. After Alzheimer's disease, FTD is the form of dementia that occurs most frequently in patients younger than 65.
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Researchers from the University of Pennsylvania School of Medicine are developing a novel approach to screen for drugs to combat neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, using yeast cells. In recent months a number of mutations have been found in a disease protein called TDP-43, which is implicated in ALS and certain types of frontotemporal dementia (FTD).
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In recent months a spate of mutations have been found in a disease protein called TDP-43 that is implicated in two neurodegenerative disorders: amyotrophic lateral sclerosis (ALS), also called Lou Gehrig’s disease, and certain types of frontotemporal dementia (FTD). These mutations could potentially become candidates for drug targets.
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UCSF scientists have identified a cell population that is a primary target of the degenerative brain disease known as frontotemporal dementia, which is as common as Alzheimer's disease in patients who develop dementia before age 65.
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Von Economo neurons (VENs) are uniquely shaped brain cells that seem to have evolved in a select group of socially complex species: great apes, humans, and, as reported last month, whales. Across species, VENs are localized to frontal brain regions associated with cognition, emotion and social behavior.
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