In standard clinical settings, DNA microarrays are currently unsuitable for routine use. Prognostic classification on formalin-fixed paraffin-embedded tissues is required. In this study, we looked for new molecular markers for identifying the prognosis of gastric cancer patients.

This study, performed by a team led by Professor Ya-Yi Hou, is described in a research article to be published in the World Journal of Gastroenterology on March 28, 2008.

Cytotoxin-associated gene A protein (CagA) from type I H.pylori has been proved by epidemiological and experimental studies to be closely associated with the H.pylori induced gastric diseases, especially gastric cancer.

A study from the Jichi Medical University in Japan shows that optimal band imaging used with an endoscope provided images that clearly identified depressed-type early gastric cancer without magnification in 96 percent of study participants.

Pepsinogen (PG) is a precursor for pepsin, a digestive enzyme specifically produced in the gastric mucosa. Human PG can be classified into two different biochemical and immunological properties, PGI and PGII. Serum PG levels seem to be related to the morphologic and functional changes in the stomach, and used as "serological biopsy."

Gastric cancer is one of the most common cancers in the world. Although the prognosis of gastric cancer is known to be poor, the survival rate for those who receive operative treatment is increasing recently by virtue of early diagnosis and aggressive surgical intervention.

The formation of a cancer is proven to be a multi-stage, multi-mechanism process by animal and human studies. As a definite carcinogen, the role of Helicobacter pylori (H pylori) in the formation of gastric cancer has been unclear.

University of Cincinnati (UC) physician-scientists believe identifying a genetic “fingerprint” could help predict which specific therapies will be most effective for patients with gastric cancer.

A new study suggests that previous estimates of the risk of gastric cancer following infection with the bacterium Helicobacter pylori may be too low. The research identifies certain strains of the bacterium associated with precancerous gastric lesions.

Researchers have identified novel genetic mutations that are linked to hereditary diffuse gastric cancer, with these mutations being due to both independent mutational events and common ancestry, according to a study in the June 6 issue of JAMA. This study is being released early to coincide with its presentation at the annual meeting of the American Society of Clinical Oncology.