Many people all over the world indulge themselves in drinking, which is correlated to a wide spectrum of medical, psychological, behavioral, and social problems. It is well known that chronic alcohol abuse may induce gastrointestinal dysfunction, chronic atrophic gastritis and is closely related with gastric carcinoma.

The Gram negative bacterium H pylori is involved in the pathogenesis of several gastrointestinal diseases, ultimately leading to gastric carcinoma. Adhesion of the bacteria to the gastric mucosa is an essential step for colonization and infection.

Pepsinogen (PG) is a precursor for pepsin, a digestive enzyme specifically produced in the gastric mucosa. Human PG can be classified into two different biochemical and immunological properties, PGI and PGII. Serum PG levels seem to be related to the morphologic and functional changes in the stomach, and used as "serological biopsy."