genomes

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Massive project reveals shortcomings of modern genome analysis

The sequencing and comparison of 12 fruit fly genomes -- the result of a massive collaboration of hundreds of scientists from more than 100 institutions in 16 countries -- has thrust forward researchers' understanding of fruit flies, a popular animal model in science.

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Completing genome sequence of fungus responsible for dandruff, skin disorders

Scientists from P&G Beauty announced that they successfully sequenced the complete genome for Malassezia globosa (M. globosa), a naturally occurring fungus responsible for the onset of dandruff and other skin conditions in humans. Results of the genome sequencing are published in today’s online edition of Proceedings of the National Academy of Sciences (PNAS).

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Massive reanalysis of genome data solves case of lethal genes

It is better to be looked over than overlooked, Mae West supposedly said. These are words of wisdom for genome data-miners of today. Data that goes unnoticed, despite its widespread availability, can reveal extraordinary insights to the discerning eye. Such is the case of a systematic analysis by the U.S. Department of Energy Joint Genome Institute (DOE JGI) of the massive backlog of microbial genome sequences from the public databases.

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Microarray sequence capture speeds large-scale resequencing of targeted genomic regions

Researchers at Baylor College of Medicine and Roche NimbleGen Inc., a fully integrated part of Roche Applied Science, have published details of a highly efficient and cost-effective method for capturing targeted regions of the genome via NimbleChip™ microarrays in preparation for high-throughput 454 Sequencing™.

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Which came first, chicken genome or egg genome?

Researchers have answered a similarly vexing (and far more relevant) genomic question: Which of the thousands of long stretches of repeated DNA in the human genome came first? And which are the duplicates?

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Fungus genome yielding answers to protect grains, people, nimals

Why a pathogen is a pathogen may be answered as scientists study the recently mapped genetic makeup of a fungus that spawns the worst cereal grains disease known and also can produce toxins potentially fatal to people and livestock.

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Pursuing future of personal genomics

Giving Nobel Laureate James Watson his personal genome was just the beginning. In a future that promises similar information to much of the population, ethicists, scientists and physicians are only beginning to understand and consider the possibilities.

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Ultraconserved Elements in Genome

Three years ago, "ultraconserved elements" were discovered in the genomes of mice, rats, and humans. These are DNA sequences 200 base pairs in length or longer — some are over 700 base pairs long — showing 100-percent identity among the three species. They have been perfectly conserved since the last common ancestor of mice, rats, and humans, which lived some 85 million years ago.

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Study sheds light on genetic link to height

It became clear nearly a century ago that many genes likely influence how tall a person grows, though little progress, if any, has followed in defining the myriad genes. Now an international research team brings light to this age-old question by pinpointing a genetic variant associated with human height — the first consistent genetic link to be reported.

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Whole-genome transfer raises questions about evolution, sequencing

Scientists at the University of Rochester and the J. Craig Venter Institute have discovered a copy of the entire genome of a bacterial parasite residing inside the genome of its host species.

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Scientists detect presence of marburg virus in african fruit bats

A collaborative team of scientists reported findings today demonstrating the presence of Marburg virus RNA genome and antibodies in a common species of African fruit bat (Rousettus aegyptiacus).

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DNA replication behavior may foreshadow leaps in genomic discoveries

For the first time, findings by scientists at the Genome Institute of Singapore (GIS) may be paving the way for more efficient analyses and tests related to the replication of cells, and ultimately, to the better understanding of human biology, such as in stem cell research.

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