New evidence in mice bolsters the notion that a version of a gene earlier shown to protect lean people against weight gain and insulin resistance can have the opposite effect in those who eat a high-fat diet and are heavier, reveals a report in the January 7th issue of the journal Cell Metabolism, a Cell Press publication.

So much for the adage, 'All things in moderation.' Researchers at the University of Calgary have found that people who consume a single, high-fat meal are more prone to suffer the physical consequences of stress than those who eat a low-fat meal.