The pigmented cells in zebrafish help scientists tease out how oncogenes that are know to contribute to cancer, influence the formation and regulation of the aggressive human skin cancer, melanoma

New genetic research suggests that the traditional risk factors for melanoma may not be as helpful in predicting risk in all people as previously thought, according to data presented at the American Association for Cancer Research 100th Annual Meeting 2009.

A protein called Mcl-1 plays a critical role in melanoma cell resistance to a form of apoptosis called anoikis, according to research published this week in Molecular Cancer Research.

Scientists have developed a new approach for surveying phosphorylation, a process that is regulated by critical cell signaling pathways and regulates several key cellular signaling events.

Every tumor, starting from a size of a few millimeters, depends on a supply of nutrients and oxygen. Therefore, using special growth factors, it induces vascular wall cells of neighboring blood vessels to sprout new capillaries in order to get connected to the blood circulation.

By targeting and disabling a protein frequently found in melanoma tumors, doctors may be able to make the cancer more vulnerable to chemotherapy, according to early results of a clinical study conducted by researchers in the Duke Comprehensive Cancer Center.

University of Michigan Health System researchers have published new data to help answer two dreaded questions: "Is it cancer?" and "What type of treatment should I have?"

For patients with a particularly aggressive form of skin cancer – malignant melanoma – stress, including that which comes from simply hearing that diagnosis, might amplify the progression of their disease.

Mobile phone use is not associated with the risk of melanoma of the eye, researchers report in the January 13 online issue of the Journal of the National Cancer Institute.

In a proportion of human solid tumors, in particular melanomas (a form of skin cancer that is often resistant to chemotherapy), inappropriate activation of the MEK/ERK signaling pathway as a result of mutations in the B-RAF gene promotes tumor cell growth and survival.

Melanoma patients infused with a special type of tumor-fighting T cell are more likely to survive without relapse, suggests a new study by researchers in France. Their report will be published online on October 20 in the Journal of Experimental Medicine.

New mouse model uncovers more effective delivery of anti-tumor vaccines for neuroblastoma and melanoma