Diets that are high in fat can shift the timing of the body’s internal clock, researchers report in the November issue of Cell Metabolism, a publication of Cell Press.

Our body’s 24-hour internal clock, or circadian clock, regulates the time we go to sleep, wake up and become hungry as well as the daily rhythms of many metabolic functions. The clock - an ancient molecular machine found in organisms large and small, simple and complex - properly aligns one’s physiology with one’s environment.

A recently published research article in the “Journal of Proteome Research”, authored by researchers from the Nestlé Reserarch Center, Genomatix Software GmbH, Rosetta Inpharmatics LLC, CXR Biosciences Ltd, the Cancer Research UK Molecular Pharmacology Unit demonstrates the synergisms and enhanced analytic power of the combination of thorough metabolic profiling with the unique and proprietary microarray analysis methods of Genomatix Software GmbH.

Researchers at the National Institutes of Health (NIH) have discovered a novel cause of iron overload in patients with thalassemia, a genetic blood disorder that causes anemia. According to the study, thalassemia patients overproduce a protein called GDF15, which suppresses the production of a liver protein, hepcidin, which in turn leads to an increase in the uptake of dietary iron in the gut.

Unique sweet pepper extract delivers natural capsinoids

Before life emerged on earth, either a primitive kind of metabolism or an RNA-like duplicating machinery must have set the stage - so experts believe. But what preceded these pre-life steps?

Why does the same diet make some of us gain more weight than others? The answer could be a molecule called Bsx, as scientists from the European Molecular Biology Laboratory [EMBL], the German Institute for Nutrition [DIFE], Potsdam, and the University of Cincinnati report in the current issue of Cell Metabolism. Bsx is the molecular link between spontaneous physical activity and food intake.

A challenging goal in biology is to understand how the principal cellular functions are integrated so that cells achieve viability and optimal fitness under a wide range of nutritional conditions.