RE1-silencing transcription factor (REST) inhibits expression of neuronal genes in non-neural cells. Huntingtin sequesters REST in the cytoplasm of neurons, precluding transcriptional repression and allowing neuronal specification.

Increases in intracellular calcium cause astrocytes to release glutamate, but evidence that this glutamate produces currents in neurons has been contradictory.

Being too brainy can be a bad thing in a junior high cafeteria, where the social hierarchy favors other traits. "Braininess" also causes problems for cells. When a breast cell begins making the proteins normally produced in neurons, for example, it can acquire cancerous properties.

Nerve growth factor (NGF), as the name says, is an essential peptide factor for the growth and differentiation of neuronal cells. Therefore we can imagine that this growth factor is important for the nervous system including brain.

Researchers at UC San Diego have discovered that iron-containing nanoparticles being tested for use in several biomedical applications can be toxic to nerve cells and interfere with the formation of their signal-transmitting extensions.