Osteoarthritis

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Meniscal damage and development of persistent knee pain

Two fibro-cartilaginous crescents, the menisci serve as cushions against joint cartilage degradation where the knee connects with the shin and thigh bones. Loss of meniscal function is recognized as a strong risk factor for knee osteoarthritis (OA).

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Long-term improvement seen with hip replacement

Total hip arthroplasty (THA), or hip replacement, is an effective treatment for osteoarthritis (OA), but most studies have only followed patients for up to one year.

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Identifying patients at high risk for total hip replacement

Osteoarthritis (OA) of the hip is a growing problem that will continue to increase as the population ages. Previous studies have reported on risk factors for developing OA, but few have examined the factors that might predict its prognosis.

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New insights into inflammation in osteoarthritis

The most common degenerative joint disease, osteoarthritis (OA) is marked by the breakdown of articular cartilage, which is the type of cartilage that lines the ends of most limb bones. It can afflict any joint—fingers, toes, wrists, ankles, elbows, shoulders, and the spine, as well as the weight-bearing knees and hips.

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Natural product discovery by Cleveland medical researchers blocks tissue destruction

Scientists at Case Western Reserve University’s School of Medicine have published in the Journal of Inflammation a remarkable discovery with a natural product derived from the Amazon rainforest. The discovery’s unique actions suggest a broad set of applications in various joint, skin and gastrointestinal diseases, including osteoarthritis and irritable bowel syndrome.

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What's been causing your knee to ache? Smurfs!

A new clinical trial seeks to predict who is most likely to experience osteoarthritis, and to test whether an experimental treatment can prevent it altogether. Physicians are setting their sights on people who sustain a knee injury, seeking to understand why nearly half of them will later go on to develop osteoarthritis, a debilitating condition that causes pain and disability in more than 20 million Americans each year.

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Effectiveness for ALO-01 similar to extended-release morphine

Alpharma Pharmaceuticals LLC, a subsidiary of Alpharma Inc.(NYSE: ALO), a leading global specialty pharmaceutical company, presented results from a Phase 2 study that showed ALO-01, an extended-release morphine sulfate plus sequestered naltrexone, provided similar effectiveness to KADIAN® (morphine sulfate extended-release) Capsules in osteoarthritis patients with moderate-to-severe chronic pain.

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Exercise for cardiovascular health keeps knee cartilage healthy

The world’s most common joint disease, osteoarthritis (OA) is a major cause of disability among adults over the age of 50. Whether physical activity is beneficial or detrimental to weight-bearing joints, knees in particular, has been open to debate.

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Short-term benefits of Physiotherapy after knee surgery

Effectiveness of physiotherapy exercise after knee arthroplasty for osteoarthritis: systematic review and meta-analysis of randomized-controlled trials

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Do static magnets reduce pain?

Static magnets are widely marketed to the public with claims of effectiveness for relieving pain. One survey suggests that about 28 percent of patients with rheumatoid arthritis, osteoarthritis or fibromyalgia, use magnets or copper bracelets for pain relief.

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New insights into common knee injuries

The sort of swelling that occurs when a joint is damaged by injury or degeneration is normally essential to the healing process, but when it comes to the knee, that inflammation can actually interfere with healing.

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Using coxibs and NSAIDs to treat osteoarthritis

In an Editorial, to be published in the international journal Osteoarthritis and Cartilage (www.intl.elsevierhealth.com), by Elsevier, a panel of arthritis research experts has recommended that coxibs and nonsteroidal anti-inflammatory drugs (NSAIDs) must remain a significant part of the tool kit used in treating osteoarthritis (OA).

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