1050 pregnant women are being recruited for the most extensive trial of its kind to establish the effect of using nicotine patches during pregnancy. The £1.3m clinical trial — Smoking, Nicotine and Pregnancy (SNAP) trial — will investigate whether nicotine replacement therapy (NRT) is safe, effective and cost-effective for mums-to-be who want to give up smoking. It will also study the effect on the behaviour and development of the child.

Children whose mothers were exposed to second-hand smoke while they were pregnant have more symptoms of serious psychological problems compared to the offspring of women who had no prenatal exposure to smoke, according to a new University of Washington study.

At least 11 percent of American women smoke during pregnancy. The negative effects of nicotine exposure to their fetuses and newborns are significant. A 2004 report by the Surgeon General, for example, found that women who smoked during pregnancy had children who were at a three times higher risk for SIDS than were the offspring of non-smokers.