Oncolytics Biotech Inc. (TSX: ONC, NASDAQ: ONCY) reported today that a research group led by Dr. Richard Vile of the Mayo Clinic College of Medicine in Rochester, Minnesota, published the results of its work testing the antitumor efficacy and safety of various combinations of reovirus and cyclophosphamide in vivo.
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In a popular children's game participants stand as close as possible without touching. But on a microscopic level, coaxing cells to be very, very close without actually touching one another has been among the most frustrating challenges for cell biologists.
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Researchers have discovered that the same genetic regulator that triggers growth of stem cells during brain development also plays a central role in the development of the lethal brain cancer malignant glioma. In experiments on mice with such gliomas, they showed that knocking out the function of a particular regulatory protein, Olig2, almost completely eliminated tumor formation.
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The movement and growth of cells are critical for normal physiological processes, and--when perturbed--can result in negative outcomes such as tumor formation.
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