Researchers at the University of Southern California (USC) have identified a specific tumor suppressor that manages membrane traffic routes for cellular cleaning and recycling.
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So vital is the p53 tumor suppressor gene in controlling cancer that its dysfunction is linked to more than half of human cancers. At the same time, the gene’s capacity for shutting down cell growth, even causing cells to commit suicide if necessary, is so absolute that it must be tightly regulated to maintain the optimal balance between protecting against cancer and permitting normal growth.
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Little-known bits of RNA help master tumor suppressor gene do its job, U-M cancer researchers find
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A well-known inflammatory protein spawns an enzyme that inactivates two tumor-suppressing genes, ultimately triggering production of new blood vessels to nourish breast cancer cells, researchers at The University of Texas M. D. Anderson Cancer Center report in the August edition of the journal Cell.
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A decades-old cancer mystery has been solved by researchers at Cold Spring Harbor Laboratory (CSHL). "We not only found a critical tumor suppressor gene, but have revealed a master switch for a tumor suppressive network that means more targeted and effective cancer therapy in the future," said CSHL Associate Professor Alea Mills, Ph.D. The study, headed by Mills, was published in the February issue of Cell.
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In the January 1 issue of G&D, Drs. Gustavo Leone and Michael Robinson (Ohio State University) and colleagues uncover a stem-cell specific role for the well-known tumor suppressor gene, Rb, in the developing mammalian embryo.
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