Researchers at Children’s Hospital of Pittsburgh of UPMC are participating in an international clinical trial currently underway to study the effectiveness of oral insulin in preventing or delaying the onset of type 1 diabetes in people at risk for the disease.

Researchers at the University of Virginia Health System have identified an enzyme thought to be an important instigator of the inner-body conflict that causes Type 1 diabetes. A chronic condition that affects nearly three million American children and adults, Type 1 diabetes is more severe than Type 2.

Type 1 diabetes is caused when immune cells attack and destroy the insulin producing beta-cells of the pancreas. Although insulin injections have changed the life of type I diabetics, they neither cure the disease nor prevent its severe complications.

A particularly bad flu season in Australia has triggered a sharp rise in the diagnosis of type 1 diabetes, say experts. They say influenza could have been the final straw for children with already compromised insulin production systems.

Researchers at Beth Israel Deaconess Medical Center (BIDMC) have found that a triple combination therapy consisting of both tolerance-inducing and anti-inflammatory properties is successful in abolishing adverse autoimmunity against insulin-producing cells in a mouse model of Type 1 diabetes.

High-quality long-term studies are lacking -- Not all studies have been fully published
There is currently no evidence available of a superiority of rapid-acting insulin analogues over human insulin in the treatment of adult patients with diabetes mellitus type 1.

Scientists say they have discovered a gene responsible for increasing a person's likelihood of contracting type 1 diabetes.

Pediatrics researchers at The Children’s Hospital of Philadelphia and McGill University in Montreal have identified a gene variant that raises a child’s risk for type 1 diabetes, formerly called juvenile diabetes. As investigators continue to pinpoint genes contributing to diabetes, they have their eyes on providing a scientific basis for designing better treatments and preventive measures for the disease.

Researchers at the University of Warwick’s Warwick Medical School have uncovered a process that locks the body’s metabolism in a diabetic state after only relatively limited exposure to high glucose levels.

Umbilical cord blood may safely preserve insulin production in children newly diagnosed with type 1 diabetes, according to findings from a small national pilot study presented Monday (June 25) at the American Diabetes Association’s 67th Scientific Sessions in Chicago.

University of Florida researchers have begun a clinical study of oral insulin to prevent or delay type 1 diabetes in people at risk for the disease.

In a fundamental discovery that someday may help cure type 1 diabetes by allowing people to grow their own insulin-producing cells for a damaged or defective pancreas, medical researchers here have reported that they have engineered adult stem cells derived from human umbilical cord blood to produce insulin.