Oxidative stress

Oxidative stress, Mechanism of cell death clarified

harminka — Wed, 03 Sep 2008 13:42:26 -0500

Dr. Marcus Conrad of the Institute of Clinical Molecular Biology and Tumor Genetics at the Helmholtz Zentrum München has decrypted the molecular mechanism through which the death of cells is caused by oxidative stress.

Increased oxidative stress in decompensated cirrhotic patients

harminka — Sat, 23 Feb 2008 12:22:04 -0600

Oxidative stress describes the state level of oxidative damage in a cell, tissue or organ, caused by reactive oxygen species. Alcohol induces oxidative stress in the liver resulting in an imbalance between oxidants and anti-oxidants.

Tool to probe role of oxidative stress in aging, disease

harminka — Fri, 15 Feb 2008 12:28:26 -0600

Oxygen, although essential for human life, can turn into an aggressive chemical that is outright toxic to important molecules inside our cells. This "oxidative stress" is associated with many diseases, such as Alzheimer's, heart disease and cancer, and has been suggested to be the culprit underlying aging.

Studying oxidative stress subcellular to discover its role in diseases

harminka — Sun, 16 Sep 2007 14:22:35 -0500

Oxidative stress is known to underlie many human diseases including atherosclerosis, Parkinson's disease and Alzheimer's disease. A team of scientists from Boston College has found a means to discover more about what role oxidative stress plays in the development of diseases by studying it at the sub-cellular level.

Role of oxidative stress in estrogen-related bone loss

harminka — Tue, 11 Sep 2007 10:39:39 -0500

Scientists have discovered new information about an immune pathway in mice that explains how oxidative stress that results from acute estrogen deficiency leads to the loss of bone. The finding, published in the Proceedings of the National Academy of Sciences, could help in identifying a new drug target for preventing postmenopausal bone loss.

Vitamin E's lack of heart benefit linked to dosage

harminka — Thu, 23 Aug 2007 05:36:01 -0500

The reported failure of vitamin E to prevent heart attacks may be due to underdosing, according to a new study by investigators at Vanderbilt University Medical Center.

Air pollution linked to cardiovascular risk indices in healthy young adults

harminka — Wed, 15 Aug 2007 08:55:36 -0500

Researchers in Taiwan have demonstrated for the first time that urban air pollution simultaneously affects key indicators of cardiovascular risk in young adults: inflammation, oxidative stress, coagulation and autonomic dysfunction.

New mechanism links smoking to lung damage

harminka — Tue, 07 Aug 2007 10:38:25 -0500

In the August 7, 2007, issue of PLoS One, researchers show how a poorly understood and previously unsuspected mechanism may be the key to understanding how life-style associated forms of oxidative stress, such as exposure to cigarette smoke, damage cells in the lungs.

Research shows NPD1 protects a key component of vision

harminka — Tue, 31 Jul 2007 03:38:55 -0500

Two papers to be published in the Early Edition online of the Proceedings of the National Academy of Sciences (PNAS) the week of July 30-August 3, 2007 report findings that demonstrate that neuroprotectin D1 (NPD1) protects against damage to retinal pigment epithelial (RPE) cells and identifies an important trigger for its production and novel molecular mechanisms that support vision.

World first medical treatment announced

harminka — Fri, 01 Jun 2007 01:41:04 -0500

Researchers at Queen Mary University London and the University of Leicester and have today (Friday June 1) announced a potential breakthrough in the treatment of a rare but devastating medical condition that can affect children and young people.

Antioxidant Supplementation for Pain Relief in Chronic Pancreatitis

harminka — Wed, 23 May 2007 04:18:21 -0500

As we continue to advance our understanding of oxidative stress and its relationship to a variety of diseases, researchers are encouraged about the potential therapeutic role for antioxidants. In this study, a team from the All India Institute of Medical Sciences in New Delhi, India, found that antioxidants may offer relief from the painful symptoms of chronic pancreatitis (CP), an ongoing inflammation of the pancreas that can lead to severe GI complications.

Oxidative stress stimulates p38 MAPK-mediated tumor suppression

harminka — Mon, 12 Feb 2007 10:47:14 -0600