amyotrophic lateral sclerosis

Proteins separation causes them to malfunction

harminka — Thu, 17 Sep 2009 11:00:47 -0500

Researchers at the Department of Biochemistry and Molecular Biology of Universitat Autònoma de Barcelona (UAB) have revealed the process by which proteins with a tendency to cause conformational diseases such as amyotrophic lateral sclerosis, familial amyloidotic polyneuropathy, familial amyloidotic cardiomyopathy, etc. finally end up causing them.

Genes linked to Lou Gehrig's disease identified

harminka — Wed, 09 Sep 2009 10:56:30 -0500

Michigan Technological University researchers have linked three genes to the most common type of amyotrophic lateral sclerosis (ALS), generally known as Lou Gehrig’s disease.

Potential mechanism identified for Lithium operation in brain

harminka — Tue, 21 Apr 2009 11:26:55 -0500

Lithium has been established for more than 50 years as one of the most effective treatments for bipolar mood disorder.

Researchers identify ALS gene mutation

harminka — Thu, 26 Feb 2009 16:39:54 -0600

Research that has discovered a new gene whose mutations cause 5 percent of inherited cases of ALS (amyotrophic lateral sclerosis) is part of a national study led by the Northwestern University Feinberg School of Medicine.

Human stem cells provide new model for Lou Gehrig's disease

harminka — Mon, 23 Feb 2009 10:16:12 -0600

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a devastating condition in which motor neuron degeneration causes progressive loss of movement and muscle tone, leading to death.

Human stem cell-based model of ALS opens doors for rapid drug screening

harminka — Wed, 03 Dec 2008 13:07:15 -0600

Long thought of as mere bystanders, astrocytes are crucial for the survival and well-being of motor neurons, which control voluntary muscle movements. In fact, defective astrocytes can lay waste to motor neurons and are the main suspects in the muscle-wasting disease amyotrophic lateral sclerosis (ALS).

Motor neurons derived from human embryonic stem cells provide insight into ALS

harminka — Wed, 03 Dec 2008 13:00:54 -0600

Two new research studies use motor neurons derived from human embryonic stem (hES) cells to demonstrate that multiple toxic pathways contribute to the devastating degeneration associated with Amyotrophic Lateral Sclerosis (ALS) and that protective therapeutics will need to oppose the disease on multiple fronts.

Novel therapeutic compounds for neurodegenerative conditions

harminka — Wed, 29 Oct 2008 11:33:20 -0500

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), disrupt the quality of life for patients, put a tremendous burden on family caregivers, and cost society billions of dollars annually.

Gene find sheds light on motor neuron diseases like ALS

harminka — Wed, 22 Oct 2008 13:03:36 -0500

Scientists have identified a gene in mice that plays a central role in the proper development of one of the nerve cells that goes bad in amyotrophic lateral sclerosis, or Lou Gehrig's disease, and some other diseases that affect our motor neurons.

Swamping bad cells with good helps sustain breathing

harminka — Mon, 20 Oct 2008 05:51:03 -0500

Swamping bad cells with good in ALS animal models helps sustain breathing

First disease-specific stem cells from human skin cells

harminka — Thu, 31 Jul 2008 14:14:14 -0500

A team of researchers from the Harvard Stem Cell Institute (HSCI) and Columbia University, in a collaboration catalyzed by the Project A.L.S./Jenifer Estess Laboratory for Stem Cell Research, has demonstrated that pluripotent stem cells generated from a patient with ALS (amyotrophic lateral sclerosis) can be directed to differentiate into motor neurons—the very brain cells destroyed by ALS.

Neurons created from skin cells of elderly ALS patients

harminka — Thu, 31 Jul 2008 14:10:06 -0500

Less than 27 months after announcing that he had institutional permission to attempt the creation of patient and disease-specific stem cell lines, Harvard Stem Cell Institute (HSCI) Principal Faculty member Kevin Eggan today proclaimed the effort a success - though politically imposed restrictions and scientific advances prompted him to use a different technique than originally planned.