Systemic lupus erythematosus

Blocked protein prevents Lupus in mouse model

harminka — Wed, 21 Jan 2009 13:08:06 -0600

Mice from a strain that ordinarily develops systemic lupus erythematosus (SLE), but bred with a deficiency in receptor for the protein Interleukin 21, stayed healthy and exhibited none of the symptoms of the disease, researchers at The Jackson Laboratory and National Institutes of Health report.

Despite Risks, Powerful Drugs Offer Hope and Relief to Autoimmune Patients

gstone — Mon, 11 Aug 2008 09:04:53 -0500

New Survey by Applied Data Research Analyzes Therapeutic and Commercial Factors in Treating Autoimmune Diseases

Specific location of TRAF1/C5 gene associated with multiple autoimmune diseases

harminka — Sat, 14 Jun 2008 01:28:07 -0500

The TRAF1/C5 locus on chromosome 9 has been revealed to play a role in multiple autoimmune diseases including type 1 diabetes and systemic lupus erythematosus (SLE), according to new data presented today at EULAR 2008, the Annual Congress of the European League Against Rheumatism in Paris, France.

Ovarian function, fertility preserved in women with severe systemic lupus erythematosus

harminka — Thu, 12 Jun 2008 09:24:38 -0500

Ovarian function can be preserved and disease activity controlled in women with severe systemic lupus erythematosus (SLE) when treated with a 6-month course of cyclophosphamide (CYC), a chemotherapy drug, followed by the immunosuppressant mycophenolate mofetil (MMF), according to a new study presented today at EULAR 2008, the Annual Congress of the European League Against Rheumatism in Paris, France.

Autoantibodies and neuropsychiatric events in lupus

harminka — Thu, 28 Feb 2008 07:10:00 -0600

Systemic lupus erythematosus (SLE), commonly known as lupus, can affect nearly any part of the body, including the joints, skin, kidneys, heart, nervous system, and brain. Along with joint pain, muscle pain, unexplained fever, extreme fatigue, and skin rashes, neurologic and psychiatric events often accompany this autoimmune disease.

Several genes that regulate the disease SLE have been identified

harminka — Tue, 22 Jan 2008 11:56:49 -0600

Swedish researchers, in collaboration with foreign colleagues, have identified a number of new genes that can be tied to the disease systemic lupus erythematosus, including a gene that hopefully might be used to treat the disease in the future by regulating the production of antibodies.

Scientists identify genes linked to lupus in women

harminka — Mon, 21 Jan 2008 07:15:50 -0600

An international consortium of scientists has identified multiple genes that are linked to systemic lupus erythematosus, a devastating autoimmune disease that affects between 1 million and 2 million Americans.

Steps toward Stopping Autoimmune Disease

harminka — Mon, 21 Jan 2008 07:10:38 -0600

A landmark genetic study has identified multiple genes linked to systemic lupus erythematosus (SLE), or lupus, a debilitating autoimmune disease that affects an estimated 1.4 million Americans.

Mayo Clinic shows therapy effective for reducing lupus flares

harminka — Sat, 10 Nov 2007 04:43:45 -0600

Mayo Clinic researchers have shown that an immunosuppressive drug used in organ transplant cases is effective in reducing flare-ups in patients with systemic lupus erythematosus (SLE). SLE results in inflammation of connective tissues and can involve the skin, joints and kidneys.

Sperm abnormalities seen in male lupus patients

harminka — Thu, 28 Jun 2007 11:38:13 -0500

The prognosis for systemic lupus erythematosus (SLE), an autoimmune disease that mainly affects women in their reproductive years, has improved recently, prompting a shift toward improving quality of life. For men with SLE, concerns have been raised about their future fertility.

Refractory lupus patients remain stable at long term follow-up

harminka — Thu, 14 Jun 2007 11:31:46 -0500

36% of patients with refractory systemic lupus erythematosus (SLE or lupus) remain well after undergoing B-cell depletion therapy (BCDT) without needing further standard immunosuppressive agents, according to a study presented today at EULAR 2007, the Annual European Congress of Rheumatology in Barcelona, Spain.

Improvement in symptoms in lupus patients at 52 weeks

harminka — Thu, 14 Jun 2007 11:27:21 -0500

Treatment with belimumab resulted in a sustained improvement of systemic lupus erythematosus (SLE or lupus) disease activity in 46% of patients at week 52, according to a novel combined responder index in results presented today at EULAR 2007, the Annual European Congress of Rheumatology in Barcelona, Spain.