DNA damage

Study Sheds Light On DNA Mechanisms

harminka — Fri, 17 Jul 2009 15:05:34 -0500

By manipulating individual atoms in DNA and forming unique molecules, a Georgia State University researcher hopes to open new avenues in research towards better understanding the mechanisms of DNA replication and transcription, and perhaps leading to new treatments for diseases.

Tumor-suppressing Protein Allows to Overcome Barrier to DNA Access

harminka — Sat, 20 Jun 2009 01:09:18 -0500

Like a mechanic popping the hood of a car to get at a faulty engine, a tumor-suppressing protein allows cellular repair mechanisms to pounce on damaged DNA by overcoming a barrier to DNA access.

New step in DNA damage response in neurons discovered

harminka — Sun, 18 Jan 2009 13:30:23 -0600

Researchers have identified a biochemical switch required for nerve cells to respond to DNA damage.

Aerosol toxins from red tides may cause long-term health threat

harminka — Thu, 10 Jul 2008 07:31:35 -0500

NOAA scientists reported in the current issue of the journal Environmental Health Perspectives that an algal toxin commonly inhaled in sea spray, attacks and damages DNA in the lungs of laboratory rats.

Why tumor cells become resistant

harminka — Mon, 23 Jun 2008 11:29:32 -0500

Cells with irreparable DNA damage normally induce programmed cell death, or apoptosis. However, this mechanism often fails in tumor cells so that transformed cells are able to multiply and spread throughout the body.

MIT confirms link between inflammation, cancer

harminka — Tue, 03 Jun 2008 02:01:20 -0500

Chronic inflammation of the intestine or stomach can damage DNA, increasing the risk of cancer, MIT scientists have confirmed.

Handheld DNA detector

harminka — Tue, 11 Mar 2008 09:35:52 -0500

A researcher at the National University at San Diego has taken a mathematical approach to a biological problem - how to design a portable DNA detector.

High zinc status in lung cells slows growth and induces DNA damage-induced gene expression

harminka — Mon, 25 Feb 2008 13:32:42 -0600

Researchers at the University of Maryland at College Park have discovered that Normal Human Bronchial Epithelial (NHBE) cells cultured in medium with elevated zinc level, at the high end of plasma zinc attainable by oral supplementation, demonstrated inhibition of cell growth, up-regulation of growth arrest and DNA damage-induced gene (Gadd45) mRNA and protein expression, and blockage of G2/M cell cycle progression.

Evolution of human genome gives people unique protections from DNA damage

harminka — Thu, 17 Jan 2008 08:04:35 -0600

Human evolution has created enhancements in key genes connected to the p53 regulatory network – the so-called guardian of the genome – by creating additional safeguards in human genes to boost the network’s ability to guard against DNA damage that could cause cancer or a variety of genetic diseases, an international team of scientists led by Cincinnati Children’s Hospital Medical Center writes in the Jan. 22 Proceedings of the National Academy of Sciences.

Gender differences in antioxidant activity, DNA damage, vasculature

harminka — Fri, 07 Dec 2007 13:00:54 -0600

A novel study in mice suggests that men are more prone to developing cancer than women because of gender differences in antioxidant levels and the ability to repair DNA damage.

DNA damage response confers barrier for viral tumorigenesis

harminka — Fri, 28 Sep 2007 15:24:04 -0500

Kaposi’s sarcoma herpesvirus (KSHV) is a human tumor virus and an etiological agent for Kaposi’s sarcoma (KS). KSHV infection is endemic in sub-Saharan Africa where KS is nowadays the most common malignancy, due to widespread infection with KSHV and human immunodeficiency virus (HIV).

New way discovered antioxidants fight debilitating diseases

harminka — Mon, 20 Aug 2007 08:05:08 -0500

Cancer, cardiovascular diseases, Parkinson’s and Alzheimer’s are often linked to DNA damage that occurs when metal ions in the body such as iron and copper produce reactive oxygen compounds that damage human cells.