muscular dystrophy

Sarcospan, little protein for big problem

harminka — Mon, 03 Nov 2008 13:04:08 -0600

The overlooked and undervalued protein, sarcospan, just got its moment in the spotlight. Peter et al. now show that adding it to muscle cells might ameliorate the most severe form of muscular dystrophy.

Explaining exercise-induced fatigue in muscular dystrophies

harminka — Mon, 27 Oct 2008 07:16:00 -0500

A University of Iowa study suggests that the prolonged fatigue after mild exercise that occurs in people with many forms of muscular dystrophy is distinct from the inherent muscle weakness caused by the disease.

Scientists replicate diseases in the lab with new stem cell lines

harminka — Fri, 08 Aug 2008 12:37:51 -0500

A set of new stem cell lines will make it possible for researchers to explore ten different genetic disorders—including muscular dystrophy, juvenile diabetes, and Parkinson's disease—in a variety of cell and tissue types as they develop in laboratory cultures.

Scientists replicate diseases in the lab with new stem cell lines

harminka — Fri, 08 Aug 2008 12:31:44 -0500

A set of new stem cell lines will make it possible for researchers to explore ten different genetic disorders—including muscular dystrophy, juvenile diabetes, and Parkinson's disease—in a variety of cell and tissue types as they develop in laboratory cultures.

Muscle stem cell transplant boosts diseased muscle function

harminka — Fri, 11 Jul 2008 12:06:32 -0500

Researchers at the Joslin Diabetes Center have demonstrated for the first time that transplanted muscle stem cells can both improve muscle function in animals with a form of muscular dystrophy and replenish the stem cell population for use in the repair of future muscle injuries.

Purified stem cells restore muscle in mice with muscular dystrophy

harminka — Fri, 11 Jul 2008 12:01:52 -0500

By injecting purified stem cells isolated from adult skeletal muscle, researchers have shown they can restore healthy muscle and improve muscle function in mice with a form of muscular dystrophy.

Molecular basis of a form of muscular dystrophy

harminka — Wed, 30 Apr 2008 08:46:36 -0500

New study in the FASEB Journal identifies c-FLIP and calpain-3 proteins as drug targets in limb-girdle muscular dystrophy and other conditions

Drug tested for preventing muscle fiber death in muscular dystrophy

harminka — Mon, 17 Mar 2008 08:13:21 -0500

An investigational antiviral drug currently undergoing human trials in Europe for treating Hepatitis C infections may have potential to reduce muscle cell damage in Duchenne and other forms of muscular dystrophy (MD).

Long-term muscle improvements shown in gene therapy study in mice

harminka — Tue, 11 Mar 2008 11:52:25 -0500

Injecting a gene responsible for making a specific protein into a mouse that’s used as a model for muscular dystrophy can lead to long-term improvements in the animal’s muscle size and strength, a new study shows.

New gene therapy strategy for muscle-wasting diseases

harminka — Tue, 11 Mar 2008 11:21:42 -0500

Investigators in The Research Institute at Nationwide Children’s Hospital have identified the role of a protein that could potentially lead to new clinical treatments to combat musculoskeletal diseases, including Duchenne muscular dystrophy (DMD).

New stem cell technique improves genetic alteration

harminka — Sat, 08 Mar 2008 13:59:23 -0600

UC Irvine researchers have discovered a dramatically improved method for genetically manipulating human embryonic stem cells, making it easier for scientists to study and potentially treat thousands of disorders ranging from Huntington’s disease to muscular dystrophy and diabetes.

Drug fights cystic fibrosis

harminka — Wed, 06 Feb 2008 07:45:55 -0600

An experimental drug that has proven effective in treating muscular dystrophy also works for cystic fibrosis, according to researchers at the University of Alabama at Birmingham (UAB).