epithelial cancers

EGFR protects cancer cells from starvation

harminka — Mon, 05 May 2008 13:49:45 -0500

Scientists have uncovered a previously unrealized mechanism by which the epidermal growth factor receptor (EGFR), a tyrosine kinase, promotes survival of cancer cells through a kinase-independent mechanism. The research, published by Cell Press in the May issue of the journal Cancer Cell, provides a rationale for the less than impressive results of recent clinical trials aimed solely at interfering with kinase activity and suggests new directions for potential therapeutic strategies.

Calorie restriction inhibits, obesity fuels development of epithelial cancers

harminka — Mon, 14 Apr 2008 13:34:25 -0500

A restricted-calorie diet inhibited the development of precancerous growths in a two-step model of skin cancer, reducing the activation of two signaling pathways known to contribute to cancer growth and development, researchers at The University of Texas M. D. Anderson Cancer Center report today at the American Association for Cancer Research annual meeting.

Cells united against cancer

harminka — Tue, 28 Aug 2007 04:58:23 -0500

Sheets of highly organized epithelial cells line all the cavities and free surfaces of the body, forming barriers that control the movement of liquids and cells in the body organs. The organized structure of normal breast epithelial cells may also serve as a barrier against cancer, according to a study by University of Helsinki scientists. The work appears this week in the online edition of the Proceedings of the National Academy of Sciences (PNAS).

Cease and desist -- genome stability and epithelial carcinogenesis

harminka — Mon, 01 Jan 2007 02:57:22 -0600