inflammation

Effects of the direct lipoprotein-associated phospholipase A2 inhibitor darapladib

harminka — Tue, 02 Sep 2008 14:28:41 -0500

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is expressed abundantly in the necrotic core of coronary lesions and products of its enzymatic activity may contribute to inflammation and cell death, rendering plaque vulnerable to rupture.

New role of inflammatory protein in PKD and a possible treatment

harminka — Tue, 17 Jun 2008 08:30:50 -0500

The Stowers Institute’s Rong Li Lab has discovered that a protein previously shown to have a role in inflammation may also have a role in the formation of cysts in Autosomal Dominant Polycystic Kidney Disease (ADPKD) — one of the most common life-threatening genetic diseases — and has shown that a drug inhibiting the protein can slow the disease in mice.

Inflammation triggers cell fusions that could protect neurons, Stanford research shows

harminka — Mon, 21 Apr 2008 02:06:28 -0500

Chronic inflammation triggers bone marrow-derived blood cells to travel to the brain and fuse with a certain type of neuron up to 100 times more frequently than previously believed, according to a new study from the Stanford University School of Medicine.

Researcher finds new defense mechanism against intestinal inflammation

harminka — Wed, 12 Mar 2008 13:16:10 -0500

The body’s first line of defence against pathogenic bacteria that we ingest may not be the immune system but rather the cells that line the intestine. This surprising conclusion is just one facet of a study by Dr. Maya Saleh, a researcher at the Research institute of the McGill University Health Centre that will be published in the journal Cell Host & Microbe on March 12.

Injection of human umbilical cord blood helps the aging brain

harminka — Tue, 11 Mar 2008 11:28:00 -0500

When human umbilical cord blood cells (UCBC) were injected into aged laboratory animals, researchers at the University of South Florida (USF) found improvements in the microenvironment of the hippocampus region of the animals’ brains and a subsequent rejuvenation of neural stem/progenitor cells.

Positive results from phase 1 clinical trials of cuprindro

harminka — Fri, 15 Feb 2008 13:31:13 -0600

Medical Therapies Limited today announced that it has completed its ‘first in human’ clinical trial of Cuprindo with interim results from patient diaries indicating that Cuprindo™ is safe and well tolerated.

Powerful tool to study the genetics of inflammation

harminka — Sat, 01 Dec 2007 12:35:34 -0600

Scientists have known which genes are linked to inflammation, but now researchers at Wake Forest University Baptist Medical Center have organized this information to develop a powerful tool to aid investigators in studying the genetics of inflammatory diseases.

Novel pathway to increased inflammation in diabetes patients

harminka — Tue, 27 Nov 2007 23:30:14 -0600

Researchers at UC Davis Health System have discovered a novel pathway that results in increased inflammation of blood vessels in patients with type 1 diabetes. Their findings suggest that, with good diabetes control, this inflammation may be reduced, possibly resulting in a reduction of cardiovascular disease as well.

Potential drug targets in autoinflammatory disease

harminka — Tue, 13 Nov 2007 08:55:41 -0600

Molecular biologists at Jefferson’s Kimmel Cancer Center in Philadelphia have detailed the cascade of cellular events behind some potentially dangerous autoinflammatory diseases. In doing so, they not only have gained a greater understanding of the disease process, but have also identified new potential drug targets for diseases ranging from arthritis to cancer.

Anti-inflammation molecule helps fight MS-like disease

harminka — Sun, 11 Nov 2007 14:20:51 -0600

An immune system messenger molecule that normally helps quiet inflammation could be an effective tool against multiple sclerosis (MS).

Could vitamin D, key milk nutrient, affect how you age?

harminka — Fri, 09 Nov 2007 08:42:59 -0600

There is a new reason for the 76 million baby boomers to grab a glass of milk. Vitamin D, a key nutrient in milk, could have aging benefits linked to reduced inflammation, according to a new study published in the American Journal of Clinical Nutrition.

Inflammation is cause of insulin resistance

harminka — Tue, 06 Nov 2007 13:04:16 -0600

Researchers at the University of California, San Diego (UCSD) School of Medicine have discovered that inflammation provoked by immune cells called macrophages leads to insulin resistance and Type 2 diabetes.